MYC and familial pancreatic carcinoma: Conversely, decreased level of miRNA-195 have been associated with increased expression of C-myc, a downstream target of Wnt signaling in in PANC-1 and AsPC-1 cells [111] Reduced level of miRNA-148a has also been linked to inhibition of Wnt signaling in pancreatic cancer, with its restoration leading to decreased tumor growth and invasion by downregulating β-catenin and C-myc levels in PANC-1 cells [112].