The overexpression of miRNA-10a has been observed to down-regulate the transcriptional suppressors and metastatic factors (homeobox transcription factors)—HOX (HOXB1, HOXB2, HOXA1) in various pancreatic cancer cell lines including, PANC-1, CAPAN-1, SUIT-2, KP-2 and MIA PaCa-2. This evidence concerns the gene HOXA1 and pancreatic neoplasm.