KIF1A and amyotrophic lateral sclerosis: Evolutionary conservation of altered amino acids of KIF1A mutation is associated with ALS, and we found that the amino acid at position 1457 of the KIF1A protein is highly conserved across multiple species, including Pan troglodytes, Macaca mulatta, Mus musculus, Drosophila melanogaster, and Caenorhabditis elegans, etc. (Figure 1G).