KITLG and myelodysplastic syndrome: In more detail, SCF is known to be involved in maintaining the HSC niche within BM to provide a supportive environment for haematopoiesis; for this reason, a decrease in SCF expression might disrupt the integrity of the niche, affecting the interactions between HSCs and the BMME and the self-renewal/differentiation of HSCs, contributing to MDS pathogenesis.