Granulocytic myeloid-derived suppressor cells primed with CML-MSCs exhibited an increase in immunomodulatory factors, including TNF-α, IL-1β, Arginase-1, IL-6, and cyclooxygenase 2 (COX-2), thereby supporting the contribution of MSCs to tumorigenesis [77]. The gene discussed is PTGS2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.