Similarly, Zhu et al. investigated the impact of MSCs derived from human adipose tissue on the K562 CML cell line and found that these MSCs impeded tumour cell proliferation by inducing cell cycle arrest through dickkopf-related protein 1 (DKK1) secretion [92]. This evidence concerns the gene DKK1 and chronic myelogenous leukemia, BCR-ABL1 positive.