To this notion, the increased expression of MIF we found in inflamed samples only has been correlated with numerous autoimmune diseases, such as IBD [61], and by binding to different receptor complexes, such as CD74/CD44, CD74/CXCR2, CD74/CXCR4, and CD74/CXCR4/CXCR7, the resulting outcome may differ [62], suggesting that it might contribute to time- and space-dependent differential activation of immune cells. Here, ACKR3 is linked to autoimmune disease.