LEP and metabolic syndrome: Among different risk factors affecting cardiovascular diseases (CVDs) in cancer patients, a strict interaction between adipocytes, especially white adipose cells (WAT) surrounded by immune cells, can interact with cancer cells [12], inducing adipokine dysfunctions [13], high levels of leptin [14], low levels of adiponectin [15] and interleukin-10 (IL-10) [16], insulin resistance and metabolic syndrome [17].