Notably, cancer-induced hyperuricemia, hyperkaliemia, acute kidney injury (AKI), anorexia, sarcopenia, and high systemic levels of TNF-α, IL-1β, IL-6, and IL-18 can impair heart function, induce myocardial fibrosis and cardiomyocyte atrophy [18,19,20]. The gene discussed is IL18; the disease is acute kidney injury.