In the case of hypertrophic cardiomyopathy, for instance, even though the disease is autosomal dominant, men are not as likely as women to present with pathogenic sarcomere variants; also, women of pre-menopausal age appear to be at least partially protected in the presence of myosin-binding protein C3 (MYBPC3) mutations [42]. Here, MYBPC3 is linked to hypertrophic cardiomyopathy.