VEGFA and neoplasm: Several robust findings have pointed out the mechanisms that stimulated the effects of chemotherapeutics in suppressing cell proliferation and invasion, increasing apoptosis, and reducing tumor growth in the presence of quercetin such as the inhibition of the PI3K/Akt and signal transducer and activator of transcription (Stat) 3 signaling pathways, increased expression of cleaved caspase-7 [46], activation of the mitochondrial/ROS pathway, decreased expression of the multidrug resistance-related protein (MRP1) [45], and reduced blood concentrations of growth factors like VEGF and EGF [46].