This phytoestrogen can also modulate DNA methylation in the promoter regions of retinoic acid receptor β (RARβ2), glutathione S-transferase P1 (GSTP1), Ras association domain family 1 (RASSF1A), and ephrin B2 (EPHB2) genes, which seems to be protective against PCa [469,470]. This evidence concerns the gene EPHB2 and posterior cortical atrophy.