TNF and Sepsis: Protection against severe sepsis was confirmed with the observation that TNF-α (Figure 3A), IL-1β (Figure 3B), IL-6 (Figure 3C), LDH (Figure 3E), ALT (Figure 3F) and urea (Figure 3G) levels were decreased to almost basal levels in MFX-treated mice 24 h after CLP compared to untreated mice.