Fourteen novel candidate genes for WS were identified: PDK4, DDIT4, FKBP5, DGAT2, LIPG, TDH, RGCC, CEPBD, DUSP8, METTL21EP, NELL2, UBE3D, COL4A5, and COL4A6 (Table 1). The gene discussed is COL4A5; the disease is Werner syndrome.