Among the DE genes, fourteen candidate genes for WS were identified for the first time: CEPBD, METTL21EP, DUSP8, NELL2, UBE3D, PDK4, DDIT4, FKBP5, DGAT2, LIPG, TDH, RGCC, COL4A5, and COL4A6. The gene discussed is UBE3D; the disease is Werner syndrome.