These processes involve PDK4 and DDIT4, novel candidate genes for WS, which interact with several other genes (UCP3, PFKFB3, FKBP5, SCD, DGAT2, LIPG, SESN1, ASNS, and ATF3) implicated in these BPs (Figure 4 and Figure 5). This evidence concerns the gene DDIT4 and Werner syndrome.