These processes involve PDK4 and DDIT4, novel candidate genes for WS, which interact with several other genes (UCP3, PFKFB3, FKBP5, SCD, DGAT2, LIPG, SESN1, ASNS, and ATF3) implicated in these BPs (Figure 4 and Figure 5). Here, PDK4 is linked to Werner syndrome.