In this way, the upregulation of the MYBPC1, MYBPC3, MYOZ2, TNNT2, FHL1, and CA3A genes, along with the downregulation of METTL21EP and DUSP8, which are associated with changes in muscle fiber type, are important findings for understanding the alterations in the muscle tissue affected by WS. Here, TNNT2 is linked to Werner syndrome.