Three of them (ANG1, C1QTNF3 and GPX6) showed differences across various stages of N. perurans outbreak, but only two transcripts (ANG1 and C1QTNF3) were differentially expressed between the low and high AGD prevalence stages (Figure 6), which correspond to the most significant changes in gill pathology and pathogen abundance (Figure 2 and Figure 4). The gene discussed is GPX6; the disease is argyrophilic grain disease.