Monocytes are likely involved in the pathophysiology of EEHV-HD as (1) monocytes are likely either infected by EEHV and/or contain phagocytosed viral particles, (2) tissue factor expressed by monocytes is a procoagulant, and (3) macrophages produce pro-inflammatory cytokines (e.g., tumor necrosis factor-alpha and interleukin-6) that promote inflammation and further activation of coagulation [16,24,25]. Here, TNF is linked to Huntington disease.