ESR1 and breast carcinoma: Thus, breast carcinoma cells of MCF-7, T-47D (ER+, PR+, HER2-), MDA-MB-231, 4T1 (ER-, PR-, HER2-), and HCC1954 (ER-, PR-, HER2+) lines were likewise sensitive to the action of Les-6287 and Les-6328 compounds.