HNF4A and cancer: Chen et al. demonstrated that in invasive mucinous lung adenocarcinoma (IMA), HNF4α transactivated lncRNA BC200 (brain cytoplasmic 200 lncRNA), which in turn functioned as a scaffold for the fragile X messenger ribonucleoprotein 1 (FMR1), an mRNA-binding protein that stabilizes cancer-related mRNAs and HNF4α mRNA in a positive feedback loop (Figure 2D).