As a quintessential example of a direct physical interaction-mediated lncRNA-NR cross-talk (Figure 2B), Kino et al. reported that lncRNA Gas5 can function as a GRE decoy by binding to the GR DNA-binding domain (DBD) and subsequently limiting GR binding to glucocorticoid response elements (GREs) in the target genes; this Gas5-GR interplay was demonstrated to modulate GR activity in HeLa cancer cells [156]. Here, GAS5 is linked to cancer.