Miano et al. showed that ER-regulated lncRNA Down syndrome cell adhesion molecule antisense 1 (DSCAM-AS1) was highly expressed in Erα+ breast carcinoma and its expression correlated with EMT and invasiveness, suggesting that ER-DSCAM-AS1 interplay may play an important role in breast cancer [138]. The gene discussed is DSCAM-AS1; the disease is breast carcinoma.