ESR1 and breast cancer: Yuan et al. performed a computational analysis of NGS data for ER-regulated and breast cancer-related lncRNAs and observed that Erα-regulated lncRNA 1 (ERLC1), a breast tissue specific lncRNA, was transcriptionally activated by Erα and in turn ERLC1 stabilized estrogen receptor 1 (ESR1) transcript to modulate Erα signaling, therefore emerging as a promising therapeutic target in breast cancer (Figure 2G) [140].