NRs such as AR, estrogen receptor (ER), farnesoid X receptor (FXR), glucocorticoid receptor (GR), hepatocyte nuclear factor 4 alpha (HNF4α), liver X receptors (LXR), PPARs and pregnane X receptor (PXR) function as regulators of both inflammation and cancer [92,93,94]. The gene discussed is HNF4A; the disease is cancer.