We can at this point be confident that this is probably the case for PCa cases that pattern along the LNCaP cell models, but this may not be the case for the more complex situation when the common TMPRSS2-ERG translocation is present, and almost certainly not for NEPC cases, wherein the expression of YAP is actually reduced [57] and probably inactive. Here, YAP1 is linked to posterior cortical atrophy.