WHO 2022 has eliminated the requirement of a ≥20% blast count as a diagnostic cut-off should a defining genetic abnormality such as PML/RARA in acute promyelocytic leukemia (APL) and core-binding factor AML (e.g., RUNX1-RUNX1T1, CBFB-MYH11) be present. This evidence concerns the gene RARA and acute promyelocytic leukemia.