FGFR2 and neoplasm: FGFR-2 and its isoforms clinically contribute to aggressiveness in PDAC [22]; previous studies demonstrated the correlation between the level of FGFR-2 IIIb and venous invasion and VEGF-A expression [23]; FGFR2 IIIc overexpression promoted cell proliferation and enhanced tumor growth and liver metastases in vivo [24].