FGFR1 and neoplasm: Distinct isoforms of FGFR1, such as FGFR1 IIIb and FGFR1 IIIc, exert varying influences on tumorigenesis, with IIIb suppressing tumor formation and growth in mice and IIIc promoting cell growth through mitogenic signaling via the FRS2-MAPK pathway, with the potential to increase the transformation of pancreatic ductal cells [18,19].