In cases of other squamous cell carcinomas, such as head and neck squamous cell carcinoma (HNSCC), patients with severe mutations in both TP53 and CDKN2A have a decreased survival rate and more aggressive cancer forms, suggesting that CDKN2A plays a role in suppressing metastasis [68,70]. The gene discussed is CDKN2A; the disease is head and neck squamous cell carcinoma.