Other genetic alterations in genes NOTCH1, NOTCH2, FAT1, and KMT2C and mutational signatures C > T and CC > TT have been found in both AK and cSCC; however, whether or not these mutated genes and UV signatures can reliably predict the trajectory from AK to cSCC progression is still being investigated [21]. This evidence concerns the gene NOTCH1 and skin squamous cell carcinoma.