In other SCCs, such as esophageal squamous cell carcinoma (ESCC) and hepatocellular carcinoma (HCC), FAT1 was found to be a negative regulator of the epithelial–mesenchymal transition (EMT), with the loss of function of FAT1 promoting EMT, cell growth, migration, and invasion [86,87,88]. This evidence concerns the gene FAT1 and hepatocellular carcinoma.