When examining the association of EGFR mutations with smoking, we observed that cancer patients with EGFR mutations had a significantly lower tobacco cigarette consumption than those with wild-type EGFR (median of 5 [interquartile range, IQR: 0; 17.5] vs. 40 [IQR: 30; 50] packs/year, p = 0.002), suggesting that EGFR mutagenesis occurs independently of smoking or that smoking promotes carcinogenesis through mechanisms that do not involve EGFR mutations. The gene discussed is EGFR; the disease is cancer.