ANTXR2 and familial pancreatic carcinoma: To investigate the impact of CMG2 on the cellular functions of pancreatic cancer cells, lentiviral CMG2 shRNA was employed to knockdown CMG2 expression in ASPC-1 and PANC-1 cells, while the overexpression of CMG2 was established in MiaPaCa-2 and PANC-1 cell lines using the plasmid vectors.