AMIGO3 and cancer: Lastly, five remaining genes [Adhesion Molecule With Ig Like Domain 3 (AMIGO3), Cysteinyl-tRNA synthetase (CARS), DEP Domain Containing MTOR Interacting Protein (DEPTOR), IQ Motif Containing GTPase Activating Protein 2 (IQGAP2), and Ribonuclease L (RNASEL)] were downregulated in both normal and cancer tissue, indicating a possible transcript instability (Figure 3C).