Opposite to what occurs in inherited multitumoral syndromes, such as Familial Adenomatous Polyposis (FAP), where germline mutations of a single gene (i.e., APC gene) determines colon cancer in 100% of affected patients, in the present model, that is likely to occur in most frequent sporadic cancers, variable oligogenic combinations of germline mutations, that change from an individual to another, all together are responsible for the occurrence of a “susceptible” or “resistant” phenotype towards a given cancer. This evidence concerns the gene APC and malignant colon neoplasm.