Secondly, three genes [ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2 (ACAP2), Enolase3 (ENO3), and prostate stem cell antigen (PSCA)] showed an upregulation in lung cancer tissue, suggesting their role as an oncogene (Figure 3B). Here, ENO3 is linked to lung cancer.