A marked downregulation in the expression of triosephosphate isomerase 1 (TPI1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and phosphoglycerate kinase 1 (PGK1) was observed in LDT compared to SDT, thus providing a novel potential metabolomic signature for the pathological classification of iCCA patients. This evidence concerns the gene GAPDH and infantile convulsions and choreoathetosis.