Most importantly, in mouse xenograft experiments with CCLP1, an established human cell line of iCCA, we demonstrated that the simultaneous presence of blocking antibodies for THBS1, THBS2, and PEDF in the iCCA-ECF was able to drastically reduce the tumor growth and the extent of tumor infiltration in local lymph nodes [40]. This evidence concerns the gene THBS1 and neoplasm.