Among genes related to iCCA with CD, CRP (C-reactive protein) was the most upregulated, while S100P (S100 calcium-binding protein P), TFF1 (trefoil factor 1), AGR2 (anterior gradient 2, protein disulfide isomerase family member), CLDN18 (claudin 18), KRT17 (keratin 17), and CTSE (cathepsin E) were characteristic of iCCA without CD. Here, CLDN18 is linked to infantile convulsions and choreoathetosis.