CD274 and non-small cell lung carcinoma: In line with this, on the one hand, the use of cytology specimens [52,53] and circulating tumor cells [54,55] provides information on the expression of predictive biomarkers, including PD-L1, in NSCLC; on the other hand, the spatial metabolomics approach [56] and lipid profiling [57] can contribute to NSCLC subtyping.