The tumor-associated macrophages also produced the fibroblast growth factor FGFb, the carcinogenesis-related markers AhR, AhRR, CYP1A1, and immune checkpoints, i.e., immunosuppressive molecules, PD-1 localized in intracellular vesicles, and PD-L1 localized both on the plasma membrane and in intracellular vesicles (Figure 6 and Figure S3). The gene discussed is CD274; the disease is neoplasm.