In recent years, specific biomarkers such as PD-L1 (Programmed death-ligand 1), MET (Mesenchymal Epithelial Transition), RET, NTRK, PIK3CA, HER2 (human epidermal growth factor receptor), and STK11 have gained attention as crucial tools for the diagnosis, prognosis, and therapeutic management of lung cancer [86]. The gene discussed is PIK3CA; the disease is lung cancer.