In recent years, specific biomarkers such as PD-L1 (Programmed death-ligand 1), MET (Mesenchymal Epithelial Transition), RET, NTRK, PIK3CA, HER2 (human epidermal growth factor receptor), and STK11 have gained attention as crucial tools for the diagnosis, prognosis, and therapeutic management of lung cancer [86]. This evidence concerns the gene CD274 and lung cancer.