Concerning the safety, the AEs of any grade were 95.9%, the most common AEs were dry mouth (42.8%), edema (38.4%), diarrhea (34.8%), increased AST (34.3%), increased ALT (33.7%), hypertension (28.2%), skin rash (27.3%), and fatigue 23.5%. The gene discussed is GPT; the disease is hypertensive disorder.