The most common treatment-related adverse events (AEs) of any grade were increased alanine aminotransferase (ALT) (96%), increased aspartate aminotransferase (AST) (73%), hypothyroidism (69%), diarrhea (62%), palmar plantar erythrodysesthesia (58%), and skin hypopigmentation (50%). Here, GPT is linked to hypopigmentation of the skin.