To determine the risk factors for the development of distant recurrence or dissemination (non-local recurrence), we initially conducted a univariate analysis of the data of 104 patients using the following clinical and genetic variables: age, sex, KPS score on admission, MGMT promoter methylation, TERT promoter mutation, tumor location, maximum tumor size, SVZ involvement, ventricular opening, extent of resection, and postoperative ischemia. This evidence concerns the gene MGMT and neoplasm.