TGFB1 and neoplasm: MDSCs are a heterogeneous immune cell population that are generally considered to contribute to immunosuppression of the TME through direct and indirect modulation of multiple other immune cell types such as T cells, NK cells, antigen-presenting cells (APCs), and B cells [29,40] and through secretion of tumor-promoting factors such as reactive oxygen species (ROS), Arg-1, and TGF-β.