Thus, epithelial, mesenchymal, muscle and melanocytic markers were used, all five tumors being immunohistochemically positive for melanocytic markers such as HMB45 (45–100% of tumor cells, with moderate and/or intense reaction), S100 protein (50–90% of tumor cells, with moderate and/or intense reaction), Melan A (70–100% of tumor cells, with moderate and/or intense reaction) and SOX 10 (30–100% of tumor cells, with weak, moderate or intense reaction) (Figure 3 and Table 4). The gene discussed is MLANA; the disease is neoplasm.