In line with these observations, it has been shown that mAb-mediated blockade of CD47, a well-known marker of melanoma metastasis and immune evasion, coupled with a CD271 cytotoxic antibody linked to the toxin saporin (CD271S, anti-CD271 mAb-saporin), significantly impairs tumor metastatic behavior in melanoma patient-derived xenografts [94]. The gene discussed is NGFR; the disease is neoplasm.