Interestingly, Huang et al. reported that inhibiting the phosphorylation (i.e., activation) of eukaryotic translation initiation factor 4E (eIF4E) in a PTEN KO transgenic melanoma mouse model prevents tumor cell dedifferentiation, resulting in increased expression of TAAs (MART-1 and gp100), thus facilitating their recognition and eradication by cytotoxic T cells. This evidence concerns the gene EIF4E and melanoma.