In line with these observations, it has been demonstrated that Notch3 plays a key role in the maintenance of melanoma CSC plasticity; knockdown of Notch3 leads to a downregulation of the stemness markers CD133 and CD271, a depletion of the melanoma CSC subpopulation and an attenuation of the proangiogenic activity [182]. Here, NOTCH3 is linked to melanoma.