Interestingly, we recently demonstrated that melanoma CSCs release soluble factors, such as TGF-β, IL-6 and IL-8, able to promote neutrophil recruitment and their switch toward the N2 phenotype, mediated by the activation of the ERK, p38 and STAT3 signaling pathway and the concurrent overexpression of CXCR2 and NF-κB. The gene discussed is STAT3; the disease is melanoma.