The anaplastic lymphoma kinase (ALK) transcript has been shown to be overexpressed in melanoma cells and to induce CSC-like properties by promoting sphere formation and upregulating the expression of stem cell markers [365]; TAE684, a pharmacological inhibitor of ALK, in combination with a PI3K/mTOR inhibitor, reverts the stemness properties of these cells [360]. This evidence concerns the gene ALK and melanoma.