ALDH1A1 and melanoma: In line with these observations, Sarvi et al. demonstrated that, in melanoma-initiating cells, the anticancer compounds 5-nitrofurans could be metabolized by ALDH1A1/1A3 into their bioactive, cytotoxic metabolites, which in turn effectively eradicate the subpopulation of melanoma cells, which expresses high levels of ALDH1 [131].