LOX and cancer: This has been supported by the observations that LOX could convert tumor-promoting M2 type macrophages to tumor-suppressing M1 type macrophages [33], and LOX inhibited animal tumor growth and killed cancer cells with or without the inclusion of metal ions or catalase in the treatment system to amplify the H2O2’s toxicity by producing hydroxyl radicals or increasing the number of tumor-suppressing cells in the TME [29,33,34,35,36].