RRM2 and breast cancer: However, when co-transfection of DSCAM-AS1 and miR-204 is carried out, the RRM2 Ribonucleotide reductase M2 (RRM2) gene is suppressed in BC cells; thus, DSCAM-AS1/miR-204-5p/RRM2 is an important pathway in BC to support cell migration and invasion is observed [58].