A dual regulatory function of miR-204 is shown in PC, as it is suggested that it is an oncomir by attacking prostate-derived Ets factor (PDEF) and inhibiting tumor suppressor function, but as a tumor suppressor in prostate adenocarcinoma (PAC) cells, LNCaP and 22RV1 for its dual modulatory effects on the expression of key cell cycle regulators, including phosphorylation of AKT, cyclin D1, p21 WAF1, and apoptosis [28]. This evidence concerns the gene SPDEF and neoplasm.