TNFRSF11B and acute lymphoblastic leukemia: In contrast, even though we had a shorter follow-up time than Solmaz et al. [34], and without any intervention with vitamin D, we observed an increase in the RANKL concentration and the RANKL/OPG ratio, as well as a decrease in OPG level between diagnosis and remission; these results suggest that, during the early phase of ALL treatment, glucocorticoid administration mainly increased osteoclastic activity and, consequently, bone resorption in these patients.