In this sense, Solmanz et al. [34] have evaluated the effect of a combination of vitamin K2 (menaquinone-7 100 μg/day) and vitamin D3 (calcitriol 10 μg/day) on BMD, RANKL, and OPG levels, among other biochemical markers of bone turnover, in 29 patients with ALL (1.0–17 years) who were randomized into a study group (n = 15) and a control group (n = 14). The gene discussed is TNFSF11; the disease is acute lymphoblastic leukemia.