Sorcin overexpression leads to increased ABCB1 levels, ultimately enhancing drug resistance in various cancer cell lines, including those from gastric cancer, lung tumors, nasopharyngeal carcinoma, cervical carcinoma, and leukemias, while sorcin silencing reduces ABCB1 expression [31,80,83,95,96,109,110,111,116]. The gene discussed is ABCB1; the disease is gastric cancer.