SRI and ovarian carcinoma: In ovarian cancer, miR-142-5p suppresses sorcin expression by binding to the 3′-UTR of the SRI gene; interestingly, this is part of a complex homeostatic loop, since the transcription factor ZEB1 inhibits the transcription of miR-142-5p by directly binding to the E-box fragment in the miR-142 promoter region, while furthermore, ZEB1 is itself negatively regulated by sorcin [86].