Han, J. et al. 2020 and Huang, A.C. et al. 2017 showed that the diversity of the PD-1+ CD8+ TCR population in blood could indicate that there is a greater proportion of exhausted T cells that can be reactivated with ICIs, leading to a more effective immune response in patients with non-small cell lung cancer [22,23]. This evidence concerns the gene CD8A and non-small cell lung carcinoma.