In preclinical models of human hepatocellular carcinoma (HCC), cancer cells treated with cisplatin and doxorubicin upregulated IL-8 expression, but, importantly, that study demonstrated that the pre-treatment of the cancer cells with an siRNA that specifically silenced IL-8 before cisplatin/doxorubicin treatment significantly increased treatment efficacy [132]. The gene discussed is CXCL8; the disease is cancer.