TP53 and posterior cortical atrophy: In addition, genetic alterations in the androgen receptor (AR), Phosphatase and tensin homolog (PTEN), tumour protein p53 (p53), and Transmembrane Protease, Serine 2—Erythroblast Transformation-Specific (ETS)-Related Gene (TMPRSS-ERG) scientifically contribute to PCa pathophysiology by altering cellular responses and treatment sensitivities [20].