Cancer-associated fibroblasts (CAFs) within the TME are the most predominant source of ECM components, including matrix metalloproteinases (MMPs), which degrade ECM proteins and facilitate the release of IL-8 and growth factors such as VEGF-A, fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), and TGF-β. The gene discussed is CXCL8; the disease is cancer.