While discussing IL-8 and its receptors, it is important to consider other ligands for CXCR1/2 that play a role in PCa, including Gro-α, Gro-β, Gro-γ, and epithelial-derived neutrophil-activating peptide 78 (ENA-78) [27]. Here, CXCL8 is linked to posterior cortical atrophy.