Current studies investigating checkpoint inhibitors have shown that Herpesvirus Entry Mediator HVEM (also known TNF Receptor Superfamily Member 14, or TNFRSF14), expressed on several cell types, including T-cells, B-cells, NK cells, and myeloid cells, has shown promising results as an immune checkpoint for T-cell mediated tumour control in PCa [125]. Here, TNFRSF14 is linked to neoplasm.