Previous transcriptomic studies on SCLC have reported the following: (1) elevated NOTCH signaling has been associated with responses to ICB [22], (2) patients with lower NE scores had a better response to ICB [32] and (3) the upregulation of SOX2 mediates the exclusion of CD8+ T cells from the tumor microenvironment and may play a role in mediating resistance to checkpoint blockade [33,34]. This evidence concerns the gene SOX2 and small cell lung carcinoma.