The present results also exhibit that among the amplified genes, the following eight genes involved in the cell cycle were found to be amplified in more than 5% of HGSO adenocarcinoma patients: ATAD2, ASF1B, CCNE1, CDC20, CDCA8, RECQL4, RNASEH2A, and SMC4. This evidence concerns the gene SMC4 and adenocarcinoma.