These three signatures consist of myeloid-focused cytokines (TNFa, GM-CSF, and IL-1b), chemokines (CCL3, CCL4, CCL5, CXCL9, and CXCL10), and an effector T-cell-derived cytokine (IFNg) and represent important aspects of a macrophage-based anti-tumor immune response. The gene discussed is CSF2; the disease is neoplasm.