The results of this study suggest that NRTN has a potential protective effect on MS (OR: 0.815, 95% CI: 0.689–0.964, 1.68 × 10−2, adjusted p_adj_bon = 1, p_adj_fdr = 0.307), which is consistent with the above-mentioned results from the research of GDNF families. Here, GDNF is linked to myeloid sarcoma.