Biomarkers for cerebral damage investigated in many neurological disorders such as stroke, central nervous system (CNS) tumors and epilepsy include neuron-specific enolase (NSE), S-100b protein (S-100 b), creatine kinase, lactate dehydrogenase, glial fibrillary acidic protein and myelin basic protein; however, measurement of NSE and S-100b protein is widely preferred due to good sensitivity for neuronal tissue damage and relatively low-cost processing [11,12]. The gene discussed is ENO2; the disease is nervous system disorder.