GBA1 and Parkinson disease: More specifically, GBA variants have been found to increase the risk of PD 5–30-fold, depending on age, ethnicity and the studied mutations [9]; moreover, carriers of GBA mutations have been associated with an earlier age of disease onset, more rapid motor deterioration, earlier appearance of neuropsychiatric symptoms and approximately six-fold increased risk of developing dementia compared to non-carriers [9,10,11].