N6-methyladenosine (m6A) methylation plays a crucial role in the interactions between RA-related immune cells and the inflammatory cytokines TNF-α and IL-1β, which are secreted by fibroblast-like synoviocytes (FLSs) located on the synovial membranes at the initial sites of the disease [235]. This evidence concerns the gene TNF and rheumatoid arthritis.