Several studies have demonstrated that the mRNA levels of METTL3, METTL14, WTAP, FTO, ALKBH5 and YTHDF2 are significantly reduced in the peripheral blood of SLE patients compared to healthy controls, highlighting the crucial role of m6A modifications in the disease’s pathogenesis [244,245]. This evidence concerns the gene ALKBH5 and systemic lupus erythematosus.