Based on degree ordering, the top seven proteins—glyceraldehyde-3-phosphate dehydrogenase (GAPDH), tumor necrosis factor (TNF), glycogen synthase kinase-3 beta (GSK3B), G1/S-specific cyclin-D1 (CCND1), myeloid cell leukemia-1 (MCL1), interleukin-2 (IL2), and cyclin-dependent kinase 2 (CDK2)—were identified as the core protein targets, which may be key targets for esculin in the treatment of RCC (Figure 1D). The gene discussed is GSK3B; the disease is renal cell carcinoma.