NR3C1 and myeloid sarcoma: In the context of this study, it is essential to point out that plasma progesterone levels are significantly higher in male MS patients than in healthy men [62], suggesting that the increase in progesterone may be one of the protective mechanisms in response to MS/EAE since progesterone and synthetic progestins have immunomodulatory and anti-inflammatory properties mediated by binding to progesterone or glucocorticoid receptors [63].