Treatment with BMP9 at a concentration from 10 to 50 ng/mL induced cell migration, morphological conversion from epithelial to fibroblastic cells, and the upregulation of the mesenchymal marker Vimentin while reducing the expression of E-cadherin in the HCC cell lines HLE and HepG2 [49,176]. The gene discussed is GDF2; the disease is hepatocellular carcinoma.