INS and polycystic ovary syndrome: In a recent systematic review and meta-analysis of 36 randomized controlled clinical trials with a total of 1691 PCOS patients randomized to inositol, metformin or placebo, it was demonstrated that inositol was superior to placebo and not inferior to metformin in normalizing menstrual cycles and superior to placebo in reducing BMI, blood levels of testosterone, androstenedione glucose and AUC insulin [105].