SREBF1 and Familial prostate cancer: The exposure of PC-3 prostate cancer cells to Cladosporols dramatically inhibited lipid accumulation through a negative regulation of the enzymes directly involved in lipid metabolism, including acetyl-CoenzymeA carboxylase (ACC), fatty acid synthase (FAS), fatty acid binding protein 4 (FABP4), hydroxi-methyl-glutaril-CoenzymeA reductase (HMG-CoAr), and sterol responsive element binding protein 1 (SREBP-1) [96].