There is a large list of plant extracts, mostly flavonoids and polyphenols, that are known to inhibit NF-κB and ameliorate the inflammation, even also in neuronal dis eases, such us: ginger [68] and polygalacic acid in the treatment of Alzheimer’s disease (AD) [69]; or orientin, a phenolic phytoconstituent, in PD [70]. Here, NFKB1 is linked to early-onset autosomal dominant Alzheimer disease.