Further studies have shown that xanthine oxidase (XO) [15], nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) (NOX) [16], and signals such as phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) [17], mitogen-activated protein kinase (MAPK), and NET, which are closely related to ROS production and metabolism, are abnormally active in hyperuricemia or GA development. Here, AKT1 is linked to hyperuricemia.