MAPK3 and mental disorder: This hypothesis is supported by the protein PXDN interaction network (Figure S9, [77,78]): Interactions with proteins such as MAPK3 and STAT3, whose gene expression levels were previously associated with the molecular link of ELA and adult mental disorders in [11], suggest the involvement of PXDN in neuronal inflammatory signaling as a response to ELA, which may ultimately result in altered neuronal plasticity and brain activity [79,80].