Although potentially driven by the MDD cohort and not significant in an interaction model, patients particularly showed differential PXDN methylation between high and low ELA experience, as also previously reported by Arranz et al. (2021) [18] in BPD, even though, in that case, the effect was in the opposite direction, with a hypomethylation in patients with ELA. This evidence concerns the gene PXDN and major depressive disorder.