Interestingly, the methylation alteration of cg10888111 between individuals with high and low levels of ELA was especially pronounced when considering the status of mental disorder, with significantly higher PXDN methylation detected in mentally ill patients who experienced high levels of ELA compared to mentally ill patients with low levels of ELA, supporting the finding by Arranz et al. (2021) [18], although in our study the effect was reversed. The gene discussed is PXDN; the disease is mental disorder.