The study by Yi et al. [23] emphasizes the genetic basis of CS, highlighting interactions between specific genetic loci among variants responsible for platelet activation (TXA2R rs1131882, P2Y1 rs1371097, and GPIIIa rs2317676), which had a combined impact on symptomatic carotid stenosis in patients with ischemic stroke. Here, P2RY1 is linked to Cowden syndrome 1.